Steps to reproduce:
Create a custom group for Organizations.
Add a File field to this group.
Create a profile for View/Edit User Acccount.
Add the field to this profile: select Organizations and then select then File field.
On an organization's user/edit page, a tab appears for this profile.
However, the File upload field does not appear on this tab.
I cannot verify this on demo.civicrm.org because if I create a user with an attached organization contact, this user does not have access to custom data fields.